After spotting the White Sox a 2-0 lead in the top of the first, the Red Sox went on to outscore their visitors by a margin of 7-2 the rest of the way, taking the first game of their four-game series, 7-4.
The win was Boston's 10th in their last 11 tries and fourth straight at home.
With the game tied 3-3 in the eighth, Marwin Gonzalez provided a homer, his first extra-base hit of the season. J.D. Martinez drew a bases-loaded walk and Xander Bogaerts supplied a bloop two-run double.
Starter Nick Pivetta lasted just 3.2 innings, but four relievers combined to give the Red Sox 5.1 innings of work out of the bullpen with one run allowed.
WHO: Red Sox (9-4) vs. Chicago White Sox (6-7) WHEN: 4:05 p.m. WHERE: Fenway Park SERIES TO DATE: 0-0 STARTING PITCHERS: RHP Nick Pivetta (2-0, 3.27) vs. RHP Dylan Cease (0-0, 3.86) TV/RADIO: NESN/FS1; WEEI-FM