Any momentum seized by the Red Sox Tuesday night was lost Wednesday as Chris Sale was cuffed around for three homers in a 6-3 loss to the Toronto Blue Jays.
The loss was the fourth in the last five games for the Sox.
Sale dropped to 3-8 for the first half with a 4.04 ERA.
The Red Sox led 2-0 in the third and 3-1 in the fourth as Rafael Devers singled home two and Christian Vazquez homered for the fifth time in 13 games.
But the Blue Jays used the long ball to chase Sale in the sixth.
WHO: Red Sox vs. Toronto Blue Jays
WHEN: 7:07 p.m.
WHERE: Rogers Centre
SERIES TO DATE: Boston 1-0
SEASON SERIES TO DATE: Boston 6-4
STARTING PITCHERS: LHP Chris Sale (3-7, 3.82) vs. RHP Jacob Waguespack (0-0, 4.50)
TV/RADIO: NESN/WEEI 93.7 FM
9:25 Big squander for the Red Sox, who have runners at second and third with one out, but can't produce the hit -- or even a one-out flyball -- to get a run across.
9:04 Two-run homer by Brandon Drury -- to straightaway center, no cheapie --marks the third homer of the night for Toronto and the end of Sale's outing. Five runs in 5.2 innings.
8:56 Andrew Benintendi continues to struggle mightily. He's 0-for-11 with an 0-for-3 tonight and hasn't gotten the ball out of the infield twice.
8:21 Danny Jansen drops the head of the bat on a high fastball....and Sale immediately drops his head. He knew. Ball clubbed into the second deck in left.
8:16 Christian Vazquez cranks his fifth homer in the last games. Alex Cora made the unconventional move of starting Vazquez behind the plate with Sale, instead of the usual pairing of Sandy Leon with Sale. Move pays off in the fourth when Vazquez goes deep with No. 13.
8:05 Lourdes Gurriel gets a fastball on the inner half and hits it out to straightaway center, cutting the Red Sox' lead in half.
7:54 Long rundown, in which Michael Chavis bought time for Mookie Betts and Brock Holt to advance to second and third proves valuable when Rafael Devers singles home both. Devers then takes second on the throw home. Devers has eight RBI in the last 12 innings.
7:46 Sale gets Brandon Drury on an inning-ending lineout to right to strand two, but the inning requires 21 pitches, pushing his pitch count to 39 after two innings.
7:27 Chris Sale featuring his fastball more prominently in the first inning than he did in his last outing against the White Sox. In that start, Sale relief more on his changeup and slider in the early going, to his detriment. Tonight, he uses his fastball more early.